Panitrol All Natural Herbal Pain Relief Formula is getting people off of their dangerous pain medications all over the country. It is for chronic pain... not acute pain. It is working on both types of arthritis as well as old sports injuries and accidents. Within about 5 to 10 days on the average... it reduces the intensity of the chronic pain signals generated by the body and as well desensitizing the chronic pain receptors resulting in no pain or almost no pain. On neurological pain it is hit and miss... but when it works for someone... it is a life changing experience. 

Here is the mechanism by which Panitrol successfully reduces inflammation, swelling of joints and pain.

How the Herbs in PANITROL Work

The three primary symptoms of arthritis are pain, inflammation, and swelling. They are inter-related and each can help make the symptom suite self-propagating. Panitrol mounts a three-pronged attack on these symptoms using properties from all five herbal extracts working synergistically and in concert.

Juniper:

• Compounds in Juniper block production of slow fiber (C-fiber) enhancement(+) neurotransmitters (NT’s) and possibly increase the presence of inhibitory (-)NT’s, thus reducing chronic pain signals to the brain. Some of these same compounds (certain sesquiterpene lactones among them) may reduce the migration of Substance P, a (+)NT, from the dorsal horn of the spinal column to the peripheral nerve fibers.
• Polyterpenoid compounds reduce production of prostacyclin synthetase, the enzyme needed to produce prostacyclin, one of the most aggressive of all prostaglandins, and platelet activation factor (PAF), an inflammatory compound produced by the body. Although a normally occurring component of the inflammation reaction, prostacyclin hypersensitizes peripheral pain receptors. Thus, by reducing prostacyclin levels in the tissues pain receptors are desensitized.
• Inflammatory chemokines and cytokines produced by the body create edema in the area of tissue injury or degradation by enlarging micropores in the local micro-capillary circulation, thus allowing plasma to "leak" into the area. Some of the compounds in Juniper are believed to close the leaky capillary path, thus reducing or cutting off altogether the source of the inflammatory substances and the plasma which cause the 'swollen' condition.
• Volatile oil components (4-terpineols) act as mild nephritic tissue irritants and thus increase glomerular filtration rate in the kidneys, creating a mild diuretic action. The first excess fluid to go is the edemous plasma and the soup of inflammatory biocompounds it contains.

Goldenrod:

• Goldenrod is an aquaretic, increasing renal blood flow and glomerular filtration rate without stimulating the loss of electrolytes such as sodium and chloride. Aquaretics are considered safer than many synthetic diuretics that promote the loss of electrolytes. This effect adds to the mild diuretic action of Juniper.
• Goldenrod has strong anti-inflammatory activity, attributed to flavonoids such as rutin, quercitrin, isoquercitrin, astragalin, and nicotiflorin.

Dandelion:

• Dandelion is considered the most powerful of herbal diuretics, and its action is probably the result of sesquiterpene lactones. The leaves are a rich source of potassium, which may make it the only naturally occurring potassium-sparing diuretic, although its diuretic action is likely different from that of pharmaceuticals. At very high doses (much, much higher than even during the front-loading period for Panitrol Relief), the leaves have been shown to possess diuretic effects comparable to the prescription diuretic frusemide (Lasix).
• Anti-edemic effects are the result of many phytochemicals, among them beta-amyrin and caffeic acid.
• Dandelion is also a rich source of vitamins and minerals. The leaves have a very high content of vitamin A as well as moderate amounts of vitamin D, vitamin C, various B vitamins, iron, silicon, magnesium, zinc, and manganese

Meadowsweet:

• Meadowsweet was one of the three most sacred plants used by Celtic Druids. The analgesic substance salicin was first isolated from Meadowsweet in 1827. Salicylic acid was first synthesized in 1859 and provided the basis for the commercial synthesis of acetyl salicylic acid (ASA), commonly known as aspirin. The word aspirin owes its origin to the original genus name of Meadowsweet, Spiraea, having been coined from “a” (for acetyl) and “spirin” (from Spiraea).
• The presence of aspirin-like chemicals explains Meadowsweet's action in reducing fever and relieving the pain of rheumatism in muscles and joints. Herbalists have long held that natural aspirin-like compounds acting together have a gentler, more long-lasting pharmacological effect than the synthetic aspirin.
  Meadowsweet also contains many of the anti-inflammatory phytochemicals noted in connection with other herbs above.

Willow:

• Willow, like meadowsweet, is a source of natural aspirin-like compounds collectively known as salicins.
• The "aspirin-like" compounds noted above contained in Meadowsweet and Willow extracts are various salicin compounds. They have been shown to exert physiologic action similar to ASA without the adverse side effects or allergic responses that ASA often elicits.
• To summarize the herbal action of Panitrol, pain, swelling, and inflammation are reduced by reducing transmission to the CNS, interfering with the action of what’s there and blocking production of more, and helping the body get rid of the rest through increased diuresis.

Delivery System

When herbal compounds are digested in the usual fashion, they are broken down into fragments in order for absorption into the portal vein to take place. This fragmentation not only robs them of pharmacological activity, but often causes them to be taken for foreign ‘toxins’ by the liver because they have lost their chemical signaling capability, and they are promptly filtered out. This results in very little getting to the place where it’s needed.

Research has clearly demonstrated that certain compounds enter the bloodstream many times faster than others. When pharmacologically active herbal compounds in Panitrol are conjugated with some of these certain and naturally occurring compounds to protect them from enzymatic attack, the complex altogether acts as a carrier that allows rapid absorption in the intestines.

When the complexes in Panitrol enter the blood, they do so without suffering attack by digestive enzymes and acids. Because of the pH differences between the intestinal lumen and the bloodstream they rehydrolyze, allowing one part of the complex to split off to be metabolized in the usual fashion and the herbal compounds to find their way to the site of injury. This allows the herbal compounds to be delivered to the bloodstream more completely than any other delivery system, with essentially 100% of their pharmacological activity intact because all of their 3-dimensional chemical structure is intact. Most importantly, they are not regarded as toxins or possible toxins by the liver because their activity and chemical signaling properties are intact, and so they are not filtered out hepatically

The grape extracts used in Panitrol also contain numerous analgesic and anti-inflammatory compounds such as ferulic and gentisic acids, kaempferol glucosides, salicylic acids, vitamin C, cinnamic acid, coumarin, myricetin, quercitrin, and resveratrol, which synergistically add to the pharmacological effects of the herbal ingredients.

Although the level of herbs in Panitrol is very low, the overall effect is strong because the pharmacological properties of the various phytochemicals ‘synergistically amplify’ each other, making the whole greater than the sum of its parts.